GPRASP1 Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2. Belongs to the GPRASP family. Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: Xq32
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  protein binding
Biological Process:  endosome to lysosome transport; G protein-coupled receptor catabolic process
Reference #:  Q920R4 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor associated sorting protein 1; G-protein coupled receptor-associated sorting protein 1; GASP-1; GASP1; Gprasp1; Per1 interacting protein; Per1-interacting protein; Pips
Gene Symbols: Gprasp1
Molecular weight: 151,349 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept