ATP6V0A1 Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle. Belongs to the V-ATPase 116 kDa subunit family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, ion channel; Transporter, iron
Chromosomal Location of rat Ortholog: 10q31
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; integral component of membrane; integral component of synaptic vesicle membrane; intracellular membrane-bounded organelle; intracellular organelle; melanosome; nuclear speck; perinuclear region of cytoplasm; plasma membrane; synaptic vesicle; vacuolar proton-transporting V-type ATPase complex; vacuolar proton-transporting V-type ATPase, V0 domain
Molecular Function:  ATPase binding; proton transmembrane transporter activity; proton-transporting ATPase activity, rotational mechanism
Biological Process:  ATP hydrolysis coupled proton transport; regulation of macroautophagy; toxin transport; vacuolar acidification
Reference #:  P25286 (UniProtKB)
Alt. Names/Synonyms: Atp6n1; Atp6n1a; Atp6v0a1; ATPase H+ transporting lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa); ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD); ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa); ATPase, H+ transporting, lysosomal noncatalytic accessory protein 1a; ATPase, H+ transporting, lysosomal V0 subunit a; ATPase, H+ transporting, lysosomal V0 subunit A1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; V-ATPase 116 kDa; V-ATPase 116 kDa isoform a1; v-H+ATPase subunit a1; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a isoform 1; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; vacuolar proton translocating ATPase 116 kDa subunit a; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1; Vpp1
Gene Symbols: Atp6v0a1
Molecular weight: 96,328 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
Select Structure to View Below

ATP6V0A1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept