DNAJC7 Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone
Chromosomal Location of Human Ortholog: 10q31
Cellular Component:  cytoplasm; cytosol; nucleoplasm
Molecular Function:  heat shock protein binding
Biological Process:  chaperone cofactor-dependent protein refolding
Reference #:  Q566E2 (UniProtKB)
Alt. Names/Synonyms: CCRP; cytoplasmic CAR retention protein; cytoplasmic constitutive active/androstane receptor retention protein; DnaJ (Hsp40) homolog, subfamily C, member 7; DnaJ heat shock protein family (Hsp40) member C7; Dnajc7; Dnajc7 protein; MGC105609
Gene Symbols: Dnajc7
Molecular weight: 50,101 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene