ESYT1 Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Belongs to the extended synaptotagmin family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q11
Cellular Component:  endoplasmic reticulum; extrinsic component of cytoplasmic side of plasma membrane; integral component of endoplasmic reticulum membrane; intrinsic component of endoplasmic reticulum membrane
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; identical protein binding; lipid binding; phosphatidylcholine binding; phosphatidylethanolamine binding; phosphatidylinositol binding
Biological Process:  endoplasmic reticulum-plasma membrane tethering; lipid transport
Reference #:  Q9Z1X1 (UniProtKB)
Alt. Names/Synonyms: E-Syt1; Esyt1; Extended synaptotagmin-1; extended synaptotagmin-like protein 1; Fam62a; family with sequence similarity 62 (C2 domain containing), member A; Mbc2; membrane bound C2 domain containing protein; Membrane-bound C2 domain-containing protein; MGC124625; vp115
Gene Symbols: Esyt1
Molecular weight: 121,159 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
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ESYT1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene