GABRA2
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
Chromosomal Location of rat Ortholog: 14p11 |
Cellular Component:
axon; chloride channel complex; cytoplasmic vesicle membrane; dendrite; dendrite membrane; GABA-A receptor complex; GABA-ergic synapse; inhibitory synapse; neuron projection; neuronal cell body; postsynapse; postsynaptic specialization membrane; presynaptic active zone membrane; synapse; synaptic vesicle membrane
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Molecular Function:
benzodiazepine receptor activity; chloride channel activity; extracellular ligand-gated monoatomic ion channel activity; GABA-A receptor activity; GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated monoatomic ion channel activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
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Biological Process:
chloride transmembrane transport; gamma-aminobutyric acid signaling pathway; inhibitory synapse assembly; nervous system process; neurotransmitter transport; regulation of neurotransmitter levels; regulation of postsynaptic membrane potential; regulation of presynaptic membrane potential; signal transduction; synaptic transmission, GABAergic
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Reference #:
P23576
(UniProtKB)
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Alt. Names/Synonyms: GABA(A) receptor subunit alpha-2; Gabra-2; Gabra2; gamma-aminobutyric acid (GABA) A receptor, alpha 2; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2; gamma-aminobutyric acid receptor A2 subunit; Gamma-aminobutyric acid receptor subunit alpha-2; GBRA2
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Gene Symbols: Gabra2
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Molecular weight:
51,182 Da
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Basal Isoelectric point:
9.21
Predict pI for various phosphorylation states
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