PRUNE Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. Belongs to the PPase class C family. Prune subfamily. Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.1; Hydrolase; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 2q34
Cellular Component:  cytoplasm; cytosol; focal adhesion; nucleus
Molecular Function:  exopolyphosphatase activity; inorganic diphosphatase activity; metal ion binding; phosphatase activity; tubulin binding
Biological Process:  dephosphorylation; polyphosphate catabolic process; regulation of microtubule polymerization; regulation of neurogenesis
Reference #:  Q6AYG3 (UniProtKB)
Alt. Names/Synonyms: Exopolyphosphatase PRUNE1; MGC93997; Protein prune homolog; Prune; prune exopolyphosphatase 1; Prune1
Gene Symbols: Prune1
Molecular weight: 49,998 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
Select Structure to View Below

PRUNE

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene