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PRUNE
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. Belongs to the PPase class C family. Prune subfamily. Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.1.1; Hydrolase; Nucleotide Metabolism - purine |
| Chromosomal Location of rat Ortholog: 2q34 |
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Cellular Component:
cytoplasm; cytosol; focal adhesion; nucleus
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Molecular Function:
exopolyphosphatase activity; inorganic diphosphate phosphatase activity; metal ion binding; phosphatase activity; pyrophosphatase activity; tubulin binding
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Biological Process:
regulation of microtubule polymerization; regulation of neurogenesis
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Reference #:
Q6AYG3
(UniProtKB)
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Alt. Names/Synonyms: Exopolyphosphatase PRUNE1; MGC93997; Protein prune homolog; Prune; prune exopolyphosphatase 1; Prune1
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Gene Symbols: Prune1
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Molecular weight:
49,998 Da
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Basal Isoelectric point:
4.92
Predict pI for various phosphorylation states
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