CDC42 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 5q36
Cellular Component:  apical part of cell; cell cortex; cell periphery; cell projection; cell-cell junction; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; dendritic spine; filopodium; Golgi membrane; Golgi transport complex; lamellipodium membrane; leading edge membrane; membrane; microtubule organizing center; midbody; mitotic spindle; neuron projection; neuronal cell body; phagocytic vesicle; plasma membrane; protein-containing complex; Schaffer collateral - CA1 synapse; secretory granule; spindle midzone; storage vacuole
Molecular Function:  apolipoprotein A-I receptor binding; GBD domain binding; GTP binding; GTP-dependent protein binding; GTPase activity; identical protein binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein kinase binding; Rho GDP-dissociation inhibitor binding; thioesterase binding; ubiquitin protein ligase activity
Biological Process:  actin cytoskeleton organization; actin filament branching; actin filament organization; adherens junction organization; cardiac conduction system development; Cdc42 protein signal transduction; cell division; cell junction assembly; cell projection assembly; cellular protein localization; cellular response to interferon-gamma; dendritic cell migration; dendritic spine morphogenesis; endocytosis; establishment of cell polarity; establishment of epithelial cell apical/basal polarity; establishment of Golgi localization; establishment or maintenance of apical/basal cell polarity; establishment or maintenance of cell polarity; filopodium assembly; Golgi organization; heart contraction; integrin-mediated signaling pathway; modification of synaptic structure; negative regulation of protein complex assembly; neuron fate determination; neuropilin signaling pathway; nuclear migration; nucleus localization; organelle transport along microtubule; phagocytosis, engulfment; positive regulation of actin cytoskeleton reorganization; positive regulation of catalytic activity; positive regulation of cell growth; positive regulation of cytokinesis; positive regulation of DNA replication; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of filopodium assembly; positive regulation of intracellular protein transport; positive regulation of JNK cascade; positive regulation of lamellipodium assembly; positive regulation of MAPK cascade; positive regulation of neuron apoptotic process; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of pseudopodium assembly; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of synapse structural plasticity; regulation of actin cytoskeleton organization; regulation of attachment of spindle microtubules to kinetochore; regulation of cell shape; regulation of exocytosis; regulation of filopodium assembly; regulation of lamellipodium assembly; regulation of mitotic nuclear division; regulation of modification of postsynaptic structure; regulation of protein heterodimerization activity; regulation of stress fiber assembly; response to glucose; Rho protein signal transduction; small GTPase mediated signal transduction; sprouting angiogenesis; submandibular salivary gland formation; viral RNA genome replication
Reference #:  Q8CFN2 (UniProtKB)
Alt. Names/Synonyms: Cdc42; Cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein); cell division cycle 42 homolog
Gene Symbols: Cdc42
Molecular weight: 21,259 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene