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ITPKA
Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. Activated by calcium/calmodulin. Belongs to the inositol phosphokinase (IPK) family. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 3q35 |
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Cellular Component:
cytoplasm; cytoskeleton; dendritic spine; glutamatergic synapse; nucleus; postsynaptic actin cytoskeleton
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Molecular Function:
ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; inositol tetrakisphosphate kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; small GTPase binding
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Biological Process:
actin cytoskeleton organization; cellular response to calcium ion; dendritic spine maintenance; inositol metabolic process; inositol phosphate biosynthetic process; modification of postsynaptic actin cytoskeleton; phosphatidylinositol phosphate biosynthetic process; phosphorylation; positive regulation of dendritic spine morphogenesis; regulation of synaptic plasticity; response to calcium ion
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Reference #:
P17105
(UniProtKB)
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Alt. Names/Synonyms: inositol 1,4,5-triphosphate 3-kinase; Inositol 1,4,5-trisphosphate 3-kinase A; inositol 145-triphosphate 3-kinase; Inositol-trisphosphate 3-kinase A; InsP 3-kinase A; IP3 3-kinase A; IP3K A; IP3KA; Itpka
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Gene Symbols: Itpka
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Molecular weight:
50,871 Da
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Basal Isoelectric point:
7.65
Predict pI for various phosphorylation states
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