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RAB1A
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport. Belongs to the small GTPase superfamily. Rab family. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab |
| Chromosomal Location of rat Ortholog: 14q22 |
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Cellular Component:
cytosol; early endosome; endomembrane system; endoplasmic reticulum membrane; exocytic vesicle; Golgi apparatus; Golgi membrane; melanosome; membrane; neuronal cell body; presynapse
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Molecular Function:
G protein activity; GTP binding; GTPase activity
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Biological Process:
autophagosome assembly; autophagy; cell migration; cilium assembly; COPII-coated vesicle cargo loading; defense response to bacterium; endocytosis; endoplasmic reticulum to Golgi vesicle-mediated transport; establishment of endothelial intestinal barrier; Golgi organization; growth hormone secretion; intracellular protein transport; melanosome transport; positive regulation of glycoprotein metabolic process; positive regulation of interleukin-8 production; Rab protein signal transduction; substrate adhesion-dependent cell spreading; vesicle transport along microtubule
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Reference #:
Q6NYB7
(UniProtKB)
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Alt. Names/Synonyms: Ac2-048; Rab1; RAB1, member RAS oncogene family; Rab1A; Rab1r; Ras-related protein Rab-1A
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Gene Symbols: Rab1a
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Molecular weight:
22,678 Da
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Basal Isoelectric point:
5.93
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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