ZHX1 Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. Belongs to the ZHX family. Ubiquitously expressed. Expressed in podocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 7q33
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; metal ion binding; protein heterodimerization activity; transcription corepressor activity
Biological Process:  negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated
Reference #:  Q8R515 (UniProtKB)
Alt. Names/Synonyms: Zhx1; zinc fingers and homeoboxes 1; Zinc fingers and homeoboxes protein 1; zinc-fingers and homeoboxes 1
Gene Symbols: Zhx1
Molecular weight: 97,570 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
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ZHX1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene