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PA1
Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent. Ubiquitously expressed. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of Human Ortholog: 7|7 F3 |
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Cellular Component:
histone methyltransferase complex; MLL3/4 complex; nucleus
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Molecular Function:
estrogen receptor binding; protein binding
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Biological Process:
chorion development; histone H3-K27 demethylation; histone H3-K4 methylation; positive regulation of cell cycle G1/S phase transition; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of isotype switching to IgG isotypes; positive regulation of response to DNA damage stimulus; positive regulation of transcription by RNA polymerase II; regulation of cell cycle G2/M phase transition
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Reference #:
Q99L02
(UniProtKB)
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Alt. Names/Synonyms: 2900092E17Rik; C77040; OTTMUSP00000030419; Pa1; Pagr; PAGR1; Pagr1a; PAXIP1 associated glutamate rich protein 1A; PAXIP1-associated glutamate-rich protein 1; PAXIP1-associated glutamate-rich protein 1A; PAXIP1-associated protein 1; PGR1A; PTIP-associated 1; PTIP-associated protein 1; RIKEN cDNA 2900092E17 gene
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Gene Symbols: Pa1
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Molecular weight:
27,723 Da
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Basal Isoelectric point:
4.51
Predict pI for various phosphorylation states
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