PA1 Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent. Ubiquitously expressed. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of mouse Ortholog: 7|7 F3
Cellular Component:  histone methyltransferase complex; MLL3/4 complex; nucleus
Molecular Function:  estrogen receptor binding; protein binding
Biological Process:  chorion development; histone H3-K27 demethylation; histone H3-K4 methylation; positive regulation of cell cycle G1/S phase transition; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of isotype switching to IgG isotypes; positive regulation of response to DNA damage stimulus; positive regulation of transcription by RNA polymerase II; regulation of cell cycle G2/M phase transition
Reference #:  Q99L02 (UniProtKB)
Alt. Names/Synonyms: 2900092E17Rik; C77040; OTTMUSP00000030419; Pa1; Pagr; PAGR1; Pagr1a; PAXIP1 associated glutamate rich protein 1A; PAXIP1-associated glutamate-rich protein 1; PAXIP1-associated glutamate-rich protein 1A; PAXIP1-associated protein 1; PGR1A; PTIP-associated 1; PTIP-associated protein 1; RIKEN cDNA 2900092E17 gene
Gene Symbols: Pa1
Molecular weight: 27,723 Da
Basal Isoelectric point: 4.51  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene