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capicua
Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. Expressed in fetal brain. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 7|7 A3 |
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Cellular Component:
intracellular membrane-bounded organelle; nucleoplasm; nucleus; protein-containing complex
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Molecular Function:
chromatin binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding
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Biological Process:
brain development; learning; lung alveolus development; memory; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; social behavior; transcription by RNA polymerase II
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Reference #:
Q924A2
(UniProtKB)
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Alt. Names/Synonyms: 1200010B10Rik; capicua; capicua homolog; capicua homolog (Drosophila); capicua transcriptional repressor; Cic; Kiaa0306; mKIAA0306; Protein capicua homolog
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Gene Symbols: Cic
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Molecular weight:
258,130 Da
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Basal Isoelectric point:
8.27
Predict pI for various phosphorylation states
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