KLHDC8B Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. Note: This description may include information from UniProtKB.
Chromosomal Location of human Ortholog: 3p21.31
Cellular Component:  cellularization cleavage furrow; cytoplasm; cytosol; intercellular bridge; midbody
Biological Process:  mitotic cytokinetic process; mitotic nuclear division; nuclear chromosome segregation
Disease: Lymphoma, Hodgkin, Classic
Reference #:  Q8IXV7 (UniProtKB)
Alt. Names/Synonyms: CHL; FLJ11302; kelch domain containing 8B; Kelch domain-containing protein 8B; KLD8B; KLHDC8B; MGC35097
Gene Symbols: KLHDC8B
Molecular weight: 37,676 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene