CDK10 Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK10 subfamily; CDK10 subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 16q24.3
Cellular Component:  ciliary basal body; cytoplasm
Molecular Function:  ATP binding; protein binding; protein serine/threonine kinase activity
Biological Process:  cell projection organization; negative regulation of cell proliferation; negative regulation of cilium assembly; peptidyl-threonine phosphorylation; positive regulation of MAPK cascade; regulation of actin cytoskeleton organization; traversing start control point of mitotic cell cycle
Disease: Al Kaissi Syndrome
Reference #:  Q15131 (UniProtKB)
Alt. Names/Synonyms: ALSAS; CDC2-related protein kinase; CDK10; Cell division protein kinase 10; cyclin dependent kinase 10; cyclin-dependent kinase (CDC2-like) 10; Cyclin-dependent kinase 10; cyclin-dependent kinase related protein; PISSLRE; serine/threonine protein kinase PISSLRE; Serine/threonine-protein kinase PISSLRE
Gene Symbols: CDK10
Molecular weight: 41,038 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein