WDFY1 Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 1|1 C4
Cellular Component:  cytosol; early endosome; endosome; nucleus
Molecular Function:  1-phosphatidylinositol binding; metal ion binding; protein binding
Biological Process:  positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway
Reference #:  E9Q4P1 (UniProtKB)
Alt. Names/Synonyms: 1700013B03Rik; 1700120F24Rik; FENS-1; Jr1; KIAA1435; mKIAA1435; OTTMUSP00000023842; WD repeat and FYVE domain containing 1; WD repeat and FYVE domain-containing protein 1; WD40 and FYVE domain containing 1; WD40- and FYVE domain-containing protein 1; WDF1; Wdfy1; Wdfy1 protein; ZFYVE17
Gene Symbols: Wdfy1
Molecular weight: 46,218 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
Select Structure to View Below

WDFY1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein