CHMP7 ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. Belongs to the SNF7 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 14|14 D2
Cellular Component:  cytoplasm; cytosol; ESCRT III complex; nuclear envelope; nucleus
Biological Process:  exit from mitosis; late endosome to vacuole transport; midbody abscission; mitotic metaphase plate congression; nuclear envelope reassembly; nucleus organization; protein localization to chromatin; protein transport; vacuolar transport
Reference #:  Q8R1T1 (UniProtKB)
Alt. Names/Synonyms: 4930596K11Rik; 6330407G04Rik; AI450338; AW550775; Charged multivesicular body protein 7; CHMP family, member 7; Chmp7; Chromatin-modifying protein 7; MGC29816
Gene Symbols: Chmp7
Molecular weight: 50,633 Da
Basal Isoelectric point: 5.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene