TMCC1 Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission. Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Belongs to the TEX28 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6|6 E3
Cellular Component:  cytosol; endoplasmic reticulum; integral component of membrane; membrane; rough endoplasmic reticulum
Molecular Function:  protein heterodimerization activity; protein homodimerization activity
Biological Process:  endoplasmic reticulum organization; endosomal transport; endosome membrane tubulation; membrane fission; protein heterooligomerization; protein homooligomerization
Reference #:  Q69ZZ6 (UniProtKB)
Alt. Names/Synonyms: 3632431M01Rik; Kiaa0779; mKIAA0779; Tmcc1; Tmcc1 protein; transmembrane and coiled coil domains 1; Transmembrane and coiled-coil domains protein 1
Gene Symbols: Tmcc1
Molecular weight: 71,642 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein