FEZ1 May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. Belongs to the zygin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 9|9 A4
Cellular Component:  axon; cell projection; centrosome; cytoplasm; cytoskeleton; dendrite; Golgi apparatus; growth cone; membrane; microtubule; neuronal cell body; plasma membrane
Molecular Function:  gamma-tubulin binding; protein binding; protein kinase C binding; protein N-terminus binding
Biological Process:  establishment of cell polarity; establishment of mitochondrion localization; mitochondrion morphogenesis; negative regulation of autophagosome assembly; positive regulation of anterograde axonal transport of mitochondrion; positive regulation of neuron differentiation; positive regulation of neuron projection development
Reference #:  Q8K0X8 (UniProtKB)
Alt. Names/Synonyms: fasciculation and elongation protein zeta 1 (zygin I); Fasciculation and elongation protein zeta-1; Fez1; MGC19293; UNC-76; UNC76; Zygin I; Zygin-1
Gene Symbols: Fez1
Molecular weight: 45,215 Da
Basal Isoelectric point: 4.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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FEZ1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene