FEZ1 May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. Belongs to the zygin family. Mainly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of mouse Ortholog: 9|9 A4
Cellular Component:  axon; cell projection; centrosome; cytoplasm; cytoskeleton; dendrite; Golgi apparatus; growth cone; membrane; microtubule; neuronal cell body; plasma membrane
Molecular Function:  gamma-tubulin binding; protein binding; protein kinase C binding
Biological Process:  establishment of cell polarity; establishment of mitochondrion localization; mitochondrion morphogenesis; negative regulation of autophagosome assembly; positive regulation of anterograde axonal transport of mitochondrion; positive regulation of neuron projection development
Reference #:  Q8K0X8 (UniProtKB)
Alt. Names/Synonyms: fasciculation and elongation protein zeta 1 (zygin I); Fasciculation and elongation protein zeta-1; Fez1; MGC19293; UNC-7; UNC-76; UNC7; UNC76; Zygin I; Zygin-1
Gene Symbols: Fez1
Molecular weight: 45,215 Da
Basal Isoelectric point: 4.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein