CDK20 Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CCRK subfamily; CDK family; CDK/CCRK subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 9q22.1
Cellular Component:  cilium; cytoplasm; nucleoplasm
Molecular Function:  ATP binding; protein binding
Biological Process:  cell cycle; cell division; multicellular organism development; regulation of cell cycle
Reference #:  Q8IZL9 (UniProtKB)
Alt. Names/Synonyms: CAK-kinase p42; CCRK; CDCH; CDK-activating kinase p42; CDK20; Cell cycle related kinase; cell cycle-related kinase; cell division protein kinase 20; cyclin dependent kinase 20; Cyclin-dependent kinase 20; Cyclin-dependent protein kinase H; cyclin-kinase-activating kinase p42; P42; PNQALRE
Gene Symbols: CDK20
Molecular weight: 38,695 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene