IGF2BP3 RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Belongs to the RRM IMP/VICKZ family. Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Spliceosome; Translation
Chromosomal Location of Human Ortholog: 6 B2.3|6 23.82 cM
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  mRNA 3'-UTR binding; mRNA 5'-UTR binding; nucleic acid binding; protein binding; RNA binding
Biological Process:  mRNA transport; regulation of translation
Reference #:  Q9CPN8 (UniProtKB)
Alt. Names/Synonyms: 2610101N11Rik; AA522010; AL022933; AU045931; CT98; IF2B3; IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; Igf2bp3; IMP-3; IMP3; insulin-like growth factor 2 mRNA binding protein 3; Insulin-like growth factor 2 mRNA-binding protein 3; insulin-like growth factor 2, binding protein 3; Koc13; MGC61294; mIMP-3; mimp3; Neilsen; VICKZ family member 3; Vickz3
Gene Symbols: Igf2bp3
Molecular weight: 63,575 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IGF2BP3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene