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CAMSAP1L1
Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In addition, it also reduces the velocity of microtubule polymerization. Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes. Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation. Through the microtubule cytoskeleton, regulates the autophagosome transport. Belongs to the CAMSAP1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of Human Ortholog: 1|1 E4 |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; microtubule; microtubule end
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Molecular Function:
calmodulin binding; microtubule binding; microtubule minus-end binding; protein binding; spectrin binding
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Biological Process:
axon development; cytoplasmic microtubule organization; microtubule cytoskeleton organization; negative regulation of microtubule depolymerization; neuron projection development; regulation of dendrite development; regulation of Golgi organization; regulation of microtubule polymerization; regulation of organelle organization
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Reference #:
Q8C1B1
(UniProtKB)
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Alt. Names/Synonyms: 1600013L13Rik; 4930541M15Rik; calmodulin regulated spectrin-associated protein 1-like 1; calmodulin regulated spectrin-associated protein family, member 2; Calmodulin-regulated spectrin-associated protein 1-like protein 1; Calmodulin-regulated spectrin-associated protein 2; CAMP2; Cams; Camsap1l1; Camsap2; Kiaa1078; mKIAA1078
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Gene Symbols: Camsap1l1
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Molecular weight:
164,333 Da
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Basal Isoelectric point:
6.42
Predict pI for various phosphorylation states
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