TRIM35 Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth. Involved in the cell death mechanism. Belongs to the TRIM/RBCC family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 14|14 D1
Cellular Component:  cytoplasm; nucleus
Molecular Function:  metal ion binding; protein binding; zinc ion binding
Biological Process:  apoptotic process; innate immune response; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; negative regulation of viral release from host cell; positive regulation of apoptotic process
Reference #:  Q8C006 (UniProtKB)
Alt. Names/Synonyms: 0710005M05Rik; A430106H13Rik; AW046487; hemopoietic lineage switch protein 5; HLS5; Kiaa1098; macrophage-derived apoptosis-inducing RBCC protein; Mair; mKIAA1098; NC8; Protein MAIR; protein Nc8; TRI35; Trim35; tripartite motif-containing 35; Tripartite motif-containing protein 35
Gene Symbols: Trim35
Molecular weight: 57,345 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein