AFAP1L1 May be involved in podosome and invadosome formation. Expressed in breast, colon and brain. In all 3 tissues, expressed in the microvasculature (at protein level). In addition, in the breast, found in the contractile myoepithelial cell layer which surrounds the breast ducts (at protein level). In the colon, expressed in the mucous membrane and colonic crypts and in the smooth muscle cell layer which provide movement of the colon (at protein level). In the cerebellum, localized around the Purkinje neurons and the granule cells of the granular layer, but not inside cell bodies (at protein level). Outside of the cerebellar cortex, expressed in glial cells (at protein level). Highly expressed away from the cell bodies within the dentate nucleus (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of mouse Ortholog: 18|18 E1
Cellular Component:  anchoring junction; cell projection; cytoplasm; cytoskeleton; cytosol
Molecular Function:  protein binding; SH3 domain binding
Reference #:  Q8BZI0 (UniProtKB)
Alt. Names/Synonyms: actin filament associated protein 1-like 1; Actin filament-associated protein 1-like 1; AF1L1; AFAP1-like protein 1; Afap1l1; AI173486
Gene Symbols: Afap1l1
Molecular weight: 86,638 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene