GPSM1 Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Belongs to the GPSM family. Expressed in intestinal cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, misc.
Chromosomal Location of Human Ortholog: 2|2 A3
Cellular Component:  cytoplasm; endoplasmic reticulum; Golgi apparatus; membrane; nucleoplasm; plasma membrane; protein-containing complex
Molecular Function:  G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; GTPase regulator activity; protein binding
Biological Process:  cell differentiation; multicellular organism development; negative regulation of GTPase activity; negative regulation of guanyl-nucleotide exchange factor activity; nervous system development; positive regulation of macroautophagy; regulation of G protein-coupled receptor signaling pathway
Reference #:  Q6IR34 (UniProtKB)
Alt. Names/Synonyms: 1810037C22Rik; Activator of G-protein signaling 3; Ags3; AW107933; G-protein signalling modulator 1 (AGS3-like, C. elegans); G-protein-signaling modulator 1; Gpsm1; OTTMUSP00000013667
Gene Symbols: Gpsm1
Molecular weight: 74,362 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene