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CLASP2
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Belongs to the CLASP family. Brain-specific. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 9|9 F3 |
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Cellular Component:
axonal growth cone; basal cortex; cell cortex; cell leading edge; cell projection; chromosome; chromosome, centromeric region; cortical microtubule plus-end; cytoplasm; cytoplasmic microtubule; cytoskeleton; cytosol; focal adhesion; Golgi apparatus; kinetochore; membrane; microtubule; microtubule cytoskeleton; microtubule organizing center; mitotic spindle; plasma membrane; ruffle membrane; spindle microtubule; trans-Golgi network
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Molecular Function:
actin filament binding; dystroglycan binding; microtubule binding; microtubule plus-end binding; protein binding; protein tyrosine kinase binding
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Biological Process:
cell cycle; cell division; cell migration; establishment of cell polarity; establishment of mitotic spindle localization; establishment or maintenance of cell polarity; exit from mitosis; fibroblast migration; Golgi organization; meiotic cell cycle; microtubule anchoring; microtubule cytoskeleton organization; microtubule depolymerization; microtubule nucleation; microtubule organizing center organization; mitotic spindle assembly; mitotic spindle organization; negative regulation of focal adhesion assembly; negative regulation of microtubule depolymerization; negative regulation of stress fiber assembly; negative regulation of wound healing, spreading of epidermal cells; platelet-derived growth factor receptor-beta signaling pathway; positive regulation of basement membrane assembly involved in embryonic body morphogenesis; positive regulation of epithelial cell migration; positive regulation of exocytosis; positive regulation of extracellular matrix disassembly; positive regulation of protein localization to membrane; protein localization to plasma membrane; regulation of actin cytoskeleton organization; regulation of axon extension; regulation of epithelial to mesenchymal transition; regulation of gastrulation; regulation of microtubule polymerization; regulation of microtubule polymerization or depolymerization; regulation of microtubule-based process; vesicle targeting
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Reference #:
Q8BRT1
(UniProtKB)
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Alt. Names/Synonyms: 1500004F14Rik; 8030404L10Rik; C77448; CLA; CLAP2; CLASP; Clasp2; CLASP2alpha; CLASP2beta; CLASP2gamma; CLIP associating protein 2; CLIP-associating protein 2; CLIP-associating protein CLASP2; Cytoplasmic linker-associated protein 2; Kiaa0627; mKIAA0627
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Gene Symbols: Clasp2
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Molecular weight:
140,739 Da
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Basal Isoelectric point:
8.84
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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