SOX4 Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. Testis, brain, and heart. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 13 A3.1|13 12.87 cM
Cellular Component:  cytoplasm; mitochondrion; nuclear transcription factor complex; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein heterodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription coactivator activity; transcription regulatory region sequence-specific DNA binding
Biological Process:  ascending aorta morphogenesis; atrial septum primum morphogenesis; cardiac right ventricle morphogenesis; cardiac ventricle formation; cell differentiation; cellular response to glucose stimulus; DNA damage response, detection of DNA damage; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; endocrine pancreas development; glial cell development; glial cell proliferation; glucose homeostasis; heart development; kidney morphogenesis; limb bud formation; mitral valve morphogenesis; negative regulation of cell death; negative regulation of cell proliferation; negative regulation of protein ubiquitination; neural tube formation; neuroepithelial cell differentiation; noradrenergic neuron differentiation; positive regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; positive regulation of cell proliferation; positive regulation of insulin secretion; positive regulation of N-terminal peptidyl-lysine acetylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of translation; pro-B cell differentiation; protein stabilization; regulation of protein stability; regulation of transcription, DNA-templated; response to hypoxia; skeletal system development; somatic stem cell population maintenance; spinal cord development; spinal cord motor neuron differentiation; sympathetic nervous system development; T cell differentiation; ventricular septum morphogenesis
Reference #:  Q06831 (UniProtKB)
Alt. Names/Synonyms: AA682046; OTTMUSP00000000649; Sox; Sox-4; Sox4; SRY (sex determining region Y)-box 4; SRY-box containing gene 4; Transcription factor SOX-4
Gene Symbols: Sox4
Molecular weight: 45,044 Da
Basal Isoelectric point: 7.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene