AKAP12 Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10|10 A1
Cellular Component:  cytoplasm; cytoskeleton; cytosol; membrane; neuronal cell body; plasma membrane; Schaffer collateral - CA1 synapse
Molecular Function:  adenylate cyclase binding; protein kinase A binding; receptor signaling complex scaffold activity
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; modulation of chemical synaptic transmission; negative regulation of vascular permeability; positive regulation of ERK1 and ERK2 cascade; positive regulation of hepatic stellate cell migration; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of oligodendrocyte apoptotic process; positive regulation of protein kinase A signaling; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor secretion; protein targeting; regulation of protein kinase A signaling; regulation of protein kinase C signaling; signal transduction
Reference #:  Q9WTQ5 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein (gravin) 12; A-kinase anchor protein 12; AI317366; AKA12; AKAP-12; Akap12; Gag12; gercelin; Germ cell lineage protein gercelin; Gravin; Src-suppressed C kinase substrate; Srcs5; SSe; SSeCKS; testis specific gene A12; Tsga; Tsga12; v-src suppressed transcript 5
Gene Symbols: Akap12
Molecular weight: 180,695 Da
Basal Isoelectric point: 4.39  Predict pI for various phosphorylation states
Select Structure to View Below

AKAP12

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene