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NUDT11
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Belongs to the Nudix hydrolase family. DIPP subfamily. Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.1.52; EC 3.6.1.60; Hydrolase |
| Chromosomal Location of mouse Ortholog: X|X A1.1 |
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Cellular Component:
cytoplasm; cytosol; nucleus
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Molecular Function:
bis(5'-adenosyl)-hexaphosphatase activity; bis(5'-adenosyl)-pentaphosphatase activity; diphosphoinositol-polyphosphate diphosphatase activity; endopolyphosphatase activity; m7G(5')pppN diphosphatase activity
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Biological Process:
adenosine 5'-(hexahydrogen pentaphosphate) catabolic process; diadenosine hexaphosphate catabolic process; diadenosine pentaphosphate catabolic process; diphosphoinositol polyphosphate metabolic process
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Reference #:
P0C028
(UniProtKB)
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Alt. Names/Synonyms: Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta; Diadenosine hexaphosphate hydrolase (AMP-forming); DIP; Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Diphosphoinositol polyphosphate phosphohydrolase 3-beta; DIPP-3-alpha; DIPP-3-beta; DIPP3; DIPP3 beta; DIPP3-alpha; DIPP3-beta; Dipp3a; Dipp3b; Nucleoside diphosphate-linked moiety X motif 10; Nucleoside diphosphate-linked moiety X motif 11; NUD11; nudix (nucleoside diphosphate linked moiety X)-type motif 11; Nudix motif 10; Nudix motif 11; nudix-type motif 11; Nudt10; Nudt11; OTTMUSP00000018016
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Gene Symbols: Nudt11
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Molecular weight:
18,593 Da
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Basal Isoelectric point:
5.54
Predict pI for various phosphorylation states
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