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TCF9
Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons. Belongs to the GCF family. Widely expressed in tissues and cell lines. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nucleolus |
| Chromosomal Location of mouse Ortholog: 6|6 C3 |
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Cellular Component:
cytosol; nucleolus; nucleoplasm; nucleus; U2-type post-mRNA release spliceosomal complex
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Molecular Function:
DNA binding
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Biological Process:
mRNA processing; mRNA splicing, via spliceosome; RNA splicing; spliceosomal complex assembly
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Reference #:
Q8BKT3
(UniProtKB)
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Alt. Names/Synonyms: A130099G21; AW14602; AW146020; expressed sequence AW146020; GC-rich sequence DNA binding factor 2; GC-rich sequence DNA-binding factor; GC-rich sequence DNA-binding factor 2; GCF; GCF2; GCFC2; Intron Large complex component GCFC2; OTTMUSP00000026861; TCF-9; Tcf9; Transcription factor 9
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Gene Symbols: Gcfc2
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Molecular weight:
87,442 Da
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Basal Isoelectric point:
5.41
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Wnt/ß-Catenin Signaling
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