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SYBU
Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. Isoform 3, isoform 4 and isoform 5 are expressed in HeLa cell line (at protein level). Isoform 3 is expressed in fetal and adult brain. Isoform 4 is expressed in numerous fetal tissues (brain, kidney, liver, lung, and thymus) and in adult brain, kidney, liver, lung, pancreas, colon, prostate, small intestine, testis and thymus. Isoform 5 is expressed in fetal brain, brain and small intestine. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 15|15 B3.2 |
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Cellular Component:
axon; axon cytoplasm; cell; cytosol; dense body; Golgi apparatus; integral component of membrane; intracellular membrane-bounded organelle; membrane; microtubule; vesicle
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Molecular Function:
kinesin binding; microtubule binding; syntaxin-1 binding
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Biological Process:
anterograde neuronal dense core vesicle transport; axonal transport of mitochondrion; positive regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of synaptic activity; synapse maturation
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Reference #:
Q8BHS8
(UniProtKB)
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Alt. Names/Synonyms: 5730410E15Rik; A830027B17Rik; Golgi-localized syntaphilin-related protein; Golsyn; Golsyn/Syntabulin; Kiaa1472; m-Golsyn; mKIAA1472; RIKEN cDNA 5730410E15 gene; Sybu; Syntabulin; syntabulin (syntaxin-interacting); Syntaxin-1-binding protein
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Gene Symbols: Sybu
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Molecular weight:
73,024 Da
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Basal Isoelectric point:
6.04
Predict pI for various phosphorylation states
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