SYBU Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. Isoform 3, isoform 4 and isoform 5 are expressed in HeLa cell line (at protein level). Isoform 3 is expressed in fetal and adult brain. Isoform 4 is expressed in numerous fetal tissues (brain, kidney, liver, lung, and thymus) and in adult brain, kidney, liver, lung, pancreas, colon, prostate, small intestine, testis and thymus. Isoform 5 is expressed in fetal brain, brain and small intestine. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 15|15 B3.2
Cellular Component:  axon; axon cytoplasm; cell; cytosol; dense body; Golgi apparatus; integral component of membrane; intracellular membrane-bounded organelle; membrane; microtubule; vesicle
Molecular Function:  kinesin binding; microtubule binding; syntaxin-1 binding
Biological Process:  anterograde neuronal dense core vesicle transport; axonal transport of mitochondrion; positive regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of synaptic activity; synapse maturation
Reference #:  Q8BHS8 (UniProtKB)
Alt. Names/Synonyms: 5730410E15Rik; A830027B17Rik; Golgi-localized syntaphilin-related protein; Golsyn; Golsyn/Syntabulin; Kiaa1472; m-Golsyn; mKIAA1472; RIKEN cDNA 5730410E15 gene; Sybu; Syntabulin; syntabulin (syntaxin-interacting); Syntaxin-1-binding protein
Gene Symbols: Sybu
Molecular weight: 73,024 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene