PRG-3 a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4|4 B1
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; nucleoplasm
Molecular Function:  lipid phosphatase activity; phosphatase activity; phosphatidate phosphatase activity
Biological Process:  nervous system development; phospholipid dephosphorylation; phospholipid metabolic process
Reference #:  Q8BFZ2 (UniProtKB)
Alt. Names/Synonyms: E130309F12Rik; Kiaa4247; Lipid phosphate phosphatase-related protein type 1; Lppr1; mKIAA4247; OTTMUSP00000007319; Phospholipid phosphatase-related protein type 1; Plasticity-related gene 3 protein; plasticity-related protein 3; PRG-3; Prg3; RIKEN cDNA E130309F12 gene
Gene Symbols: Lppr1
Molecular weight: 35,932 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene