BUB1 Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily. High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed in fetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: BUB family; Cell cycle regulation; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 2q13
Cellular Component:  condensed chromosome kinetochore; condensed nuclear chromosome outer kinetochore; cytosol; kinetochore; nucleoplasm
Molecular Function:  ATP binding; protein binding; protein serine/threonine kinase activity
Biological Process:  apoptotic process; cell division; cell proliferation; mitotic cell cycle checkpoint; protein phosphorylation; regulation of chromosome segregation; regulation of sister chromatid cohesion; viral process
Disease: Colorectal Cancer
Reference #:  O43683 (UniProtKB)
Alt. Names/Synonyms: BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog; BUB1 mitotic checkpoint serine/threonine kinase; BUB1A; BUB1L; budding uninhibited by benzimidazoles 1 homolog; budding uninhibited by benzimidazoles 1 homolog (yeast); hBUB1; Mitotic checkpoint serine/threonine-protein kinase BUB1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase
Gene Symbols: BUB1
Molecular weight: 122,375 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
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BUB1

Protein Structure Not Found.


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