PLCL4
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain. Expressed in retina and kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.4.11; Phospholipase |
Chromosomal Location of mouse Ortholog: 4|4 E2 |
Cellular Component:
cytoplasm; membrane; plasma membrane
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Molecular Function:
calcium ion binding; hydrolase activity; metal ion binding; phosphatidylinositol phospholipase C activity; phospholipase C activity; phosphoric diester hydrolase activity
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Biological Process:
intracellular signal transduction; lipid catabolic process; lipid metabolic process; phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; release of sequestered calcium ion into cytosol; signal transduction
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Reference #:
A2AP18
(UniProtKB)
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Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2; A930027K05Rik; Phosphoinositide phospholipase C-eta-2; Phosphoinositide phospholipase C-like 4; phospholipase C, eta 2; Phospholipase C-eta-2; phospholipase C-like 4; Phospholipase C-like protein 4; PLC-eta2; PLC-L4; PLCe; PLCeta2; Plch2; Plcl4
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Gene Symbols: Plch2
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Molecular weight:
164,297 Da
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Basal Isoelectric point:
7.33
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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