PLCL4 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain. Expressed in retina and kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.11; Phospholipase
Chromosomal Location of mouse Ortholog: 4|4 E2
Cellular Component:  cytoplasm; membrane; plasma membrane
Molecular Function:  calcium ion binding; hydrolase activity; metal ion binding; phosphatidylinositol phospholipase C activity; phospholipase C activity; phosphoric diester hydrolase activity
Biological Process:  intracellular signal transduction; lipid catabolic process; lipid metabolic process; phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; release of sequestered calcium ion into cytosol; signal transduction
Reference #:  A2AP18 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2; A930027K05Rik; Phosphoinositide phospholipase C-eta-2; Phosphoinositide phospholipase C-like 4; phospholipase C, eta 2; Phospholipase C-eta-2; phospholipase C-like 4; Phospholipase C-like protein 4; PLC-eta2; PLC-L4; PLCe; PLCeta2; Plch2; Plcl4
Gene Symbols: Plch2
Molecular weight: 164,297 Da
Basal Isoelectric point: 7.33  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below

PLCL4

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene