DCAMKL1 iso2
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; DCAMKL family; EC 2.7.11.1; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Cellular Component: axon; growth cone; postsynaptic density
Molecular Function: ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process: axon extension; axonogenesis; brain development; cell differentiation; central nervous system projection neuron axonogenesis; dendrite morphogenesis; forebrain development; intracellular signal transduction; multicellular organism development; negative regulation of protein localization to nucleus; nervous system development; neuron migration; neuron projection morphogenesis; peptidyl-serine phosphorylation; phosphorylation; protein localization to nucleus; protein phosphorylation