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Lunapark
Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. May be involved in limb development. Is involved in central nervous system development. Belongs to the lunapark family. Expressed in neural precursor cells, where it is detected at the growth-cone-like structure and branching sites of neurite-like processes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 2|2 C3 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum tubular network; endoplasmic reticulum tubular network membrane; membrane; nucleoplasm
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Molecular Function:
identical protein binding; metal ion binding
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Biological Process:
blood coagulation; embryonic digit morphogenesis; embryonic forelimb morphogenesis; endoplasmic reticulum organization; endoplasmic reticulum tubular network maintenance; endoplasmic reticulum tubular network organization; multicellular organism development; positive regulation of endoplasmic reticulum tubular network organization; regulation of chondrocyte differentiation
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Reference #:
Q7TQ95
(UniProtKB)
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Alt. Names/Synonyms: 2310011O18Rik; 4921514L11Rik; 9530051D01Rik; AI666268; Endoplasmic reticulum junction formation protein lunapark; ER junction formation factor 1; ER junction formation factor lunapark; Kiaa1715; limb and neural patterns; Lnp; Lnpk; Lnpk1; lunapark; lunapark, ER junction formation factor; OTTMUSP00000014293; Protein lunapark; Protein ulnaless; Ul; Uln; ulnaless
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Gene Symbols: Lnpk
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Molecular weight:
47,500 Da
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Basal Isoelectric point:
5.24
Predict pI for various phosphorylation states
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