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ASE-1
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex. Belongs to the eukaryotic RPA34 RNA polymerase subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nucleolus; Transcription initiation complex |
| Chromosomal Location of Human Ortholog: 7|7 A3 |
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Cellular Component:
cytosol; fibrillar center; mitochondrion; nucleolus; nucleus; RNA polymerase I complex
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Molecular Function:
protein binding
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Biological Process:
rRNA transcription; transcription by RNA polymerase I
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Reference #:
Q76KJ5
(UniProtKB)
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Alt. Names/Synonyms: 1190028F09; 2610103M17Rik; A34.5; Anti-sense to ERCC-1 protein; antisense to Ercc1; ASE-1; Ase1; CAST; CD3 epsilon associated protein; CD3-epsilon-associated protein; CD3E antigen, epsilon polypeptide associated protein; CD3E-associated protein; Cd3eap; DNA-directed RNA polymerase I subunit RPA34; Paf49; RNA polymerase I-associated factor PAF49; RPA34
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Gene Symbols: Cd3eap
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Molecular weight:
43,082 Da
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Basal Isoelectric point:
9.63
Predict pI for various phosphorylation states
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