WAPL Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Belongs to the WAPL family. Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 14|14 B
Cellular Component:  chromatin; chromosome; cohesin complex; cytoplasm; nucleus; synaptonemal complex
Biological Process:  cell cycle; cell division; meiotic chromosome segregation; mitotic cell cycle; negative regulation of chromatin binding; negative regulation of DNA replication; negative regulation of sister chromatid cohesion; positive regulation of fibroblast proliferation; protein localization to chromatin; regulation of chromosome condensation; regulation of chromosome segregation; regulation of cohesin loading; response to toxic substance
Reference #:  Q65Z40 (UniProtKB)
Alt. Names/Synonyms: 2410073G16; A530089A20Rik; BC037674; DIF-2; Dioxin-inducible factor 2; FOE; friend of EBNA2; Kiaa0261; mKIAA0261; mWAPL; OTTMUSP00000029240; Wapal; Wapl; WAPL cohesin release factor; WAPL protein; wings apart-like homolog; wings apart-like homolog (Drosophila); Wings apart-like protein homolog
Gene Symbols: Wapal
Molecular weight: 134,070 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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WAPL

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene