OGA Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity. Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. Belongs to the glycosyl hydrolase 84 family. Ubiquitous. Shows highest expression in the brain, placenta and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; EC; Hydrolase
Chromosomal Location of mouse Ortholog: 19 C3|19 38.75 cM
Cellular Component:  cytoplasm; cytosol; mitochondrion; nucleus
Molecular Function:  [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity; [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity; beta-N-acetylglucosaminidase activity; histone acetyltransferase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; protein binding
Biological Process:  dATP metabolic process; glycoprotein metabolic process; metabolic process; N-acetylglucosamine metabolic process; necrotic cell death; negative regulation of cardiac muscle adaptation; negative regulation of protein glycosylation; positive regulation of calcium ion transport; positive regulation of calcium ion transport into cytosol; positive regulation of cell killing; positive regulation of DNA metabolic process; positive regulation of glucose import; positive regulation of growth hormone secretion; positive regulation of insulin secretion; positive regulation of mitochondrial depolarization; positive regulation of protein complex disassembly; positive regulation of proteolysis; protein deglycosylation; protein targeting to membrane
Reference #:  Q9EQQ9 (UniProtKB)
Alt. Names/Synonyms: 2810009A20Rik; 4833427O07Rik; 5830447M11Rik; AA408215; Beta-hexosaminidase; Beta-N-acetylhexosaminidase; Bifunctional protein NCOAT; HAT; Hexc; Hexosaminidase C; Histone acetyltransferase; Hy5; Kiaa0679; meningioma expressed antigen 5 (hyaluronidase); Meningioma-expressed antigen 5; Mgea; Mgea5; mKIAA0679; N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; Ncoat; Nuclear cytoplasmic O-GlcNAcase and acetyltransferase; O-GlcNAcase; OGA; Protein O-GlcNAcase
Gene Symbols: Mgea5
Molecular weight: 103,162 Da
Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene