MTSS1L Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling. Belongs to the MTSS family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding
Chromosomal Location of mouse Ortholog: 8|8 E1
Cellular Component:  cell projection; cortical actin cytoskeleton; cytoplasm; lamellipodium; plasma membrane; ruffle; ruffle membrane
Molecular Function:  actin binding; actin monomer binding; GTPase activator activity; phosphatidylinositol-4,5-bisphosphate binding; Rac GTPase binding
Biological Process:  activation of GTPase activity; cellular response to platelet-derived growth factor stimulus; lamellipodium organization; membrane organization; plasma membrane organization; ruffle assembly
Reference #:  Q6P9S0 (UniProtKB)
Alt. Names/Synonyms: ABBA; metastasis suppressor 1-like; MGC79213; Mts; MTSS I-BAR domain containing 2; MTSS1-like protein; Mtss1l; MTSS2; MTSSL; Protein MTSS 2
Gene Symbols: Mtss2
Molecular weight: 76,844 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene