nestin Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. Belongs to the intermediate filament family. CNS stem cells. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 3 F1|3 38.78 cM
Cellular Component:  cytoplasm; intermediate filament
Molecular Function:  CCR5 chemokine receptor binding; intermediate filament binding; protein binding; structural molecule activity
Biological Process:  cell projection morphogenesis; multicellular organism development; negative regulation of neuron apoptotic process; nervous system development
Reference #:  Q6P5H2 (UniProtKB)
Alt. Names/Synonyms: AA166324; C78523; ESTM46; Nes; NEST; Nestin
Gene Symbols: Nes
Molecular weight: 207,124 Da
Basal Isoelectric point: 4.3  Predict pI for various phosphorylation states
Select Structure to View Below

nestin

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene