SKIC2 Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Belongs to the helicase family. SKI2 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase
Chromosomal Location of mouse Ortholog: 17|17 B1
Cellular Component:  Ski complex
Molecular Function:  3'-5' RNA helicase activity; RNA helicase activity
Biological Process:  nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; rescue of stalled ribosome
Reference #:  Q6NZR5 (UniProtKB)
Alt. Names/Synonyms: 4930534J06Rik; AW214248; Ddx13; helicase SKI2W; SKI; SKI2 subunit of superkiller complex; Ski2w; Skic2; Skiv2l; Superkiller complex protein 2; superkiller viralicidic activity 2-like; Superkiller viralicidic activity 2-like (S. cerevisiae)
Gene Symbols: Skic2
Molecular weight: 137,524 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
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SKIC2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein