USP47 Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; EC 3.4.19.12; Motility/polarity/chemotaxis; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 7|7 F1
Cellular Component:  cytoplasm; cytosol; SCF ubiquitin ligase complex
Molecular Function:  cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity; peptidase activity; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity; ubiquitinyl hydrolase activity; WD40-repeat domain binding
Biological Process:  base-excision repair; cellular response to DNA damage stimulus; cellular response to UV; DNA repair; monoubiquitinated protein deubiquitination; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription, DNA-templated; positive regulation of canonical Wnt signaling pathway; positive regulation of cell growth; protein deubiquitination; proteolysis; regulation of protein stability; response to drug; ubiquitin-dependent protein catabolic process
Reference #:  Q8BY87 (UniProtKB)
Alt. Names/Synonyms: 4930502N04Rik; A630020C16Rik; Deubiquitinating enzyme 47; MGC118655; Ubiquitin carboxyl-terminal hydrolase 47; ubiquitin specific peptidase 47; ubiquitin specific protease 47; Ubiquitin thioesterase 47; Ubiquitin-specific-processing protease 47; UBP47; Usp47
Gene Symbols: Usp47
Molecular weight: 157,455 Da
Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states
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USP47

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene