CACNA1B Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily. Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component:  calyx of Held; integral component of presynaptic membrane; voltage-gated calcium channel complex
Molecular Function:  high voltage-gated calcium channel activity; voltage-gated calcium channel activity
Biological Process:  calcium ion import; calcium ion transmembrane transport; calcium ion transport; regulation of ion transmembrane transport
Reference #:  Q9PUM6 (UniProtKB)
Alt. Names/Synonyms: CAC1B; CACNA1B; calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-dependent N-type calcium channel subunit alpha; VSCC, L type, alpha 1B
Gene Symbols: CACNA1B
Molecular weight: 266,584 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein