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NGFR
Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of rat Ortholog: 10q26 |
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Cellular Component:
cell surface; cell-cell junction; clathrin-coated endocytic vesicle; cytoplasm; dendrite membrane; dendritic spine; external side of plasma membrane; growth cone; membrane; neuromuscular junction; neuronal cell body membrane; nuclear envelope; nucleoplasm; perikaryon; plasma membrane; postsynaptic density; presynapse; presynaptic membrane
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Molecular Function:
amyloid-beta binding; calmodulin binding; coreceptor activity; death receptor activity; identical protein binding; nerve growth factor binding; neurotrophin binding; neurotrophin TRKA receptor binding; preprotein binding; protein binding; protein-containing complex binding; small GTPase binding; ubiquitin protein ligase binding
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Biological Process:
activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; axon guidance; cellular response to amyloid-beta; cellular response to oxidative stress; central nervous system development; circadian regulation of gene expression; circadian rhythm; detection of temperature stimulus; dorsal aorta development; fibroblast growth factor receptor signaling pathway; fibroblast proliferation; glucose homeostasis; hair follicle development; hair follicle morphogenesis; intracellular glucose homeostasis; intracellular protein transport; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of cell migration; negative regulation of dendritic spine development; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of hair follicle development; negative regulation of mitochondrial depolarization; negative regulation of neuron apoptotic process; negative regulation of neuron projection development; nerve development; neuron apoptotic process; odontogenesis of dentin-containing tooth; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of excitatory postsynaptic potential; positive regulation of fibroblast proliferation; positive regulation of MAPK cascade; positive regulation of miRNA transcription; positive regulation of myelination; positive regulation of neural precursor cell proliferation; positive regulation of neuron differentiation; positive regulation of neuron projection development; positive regulation of odontogenesis of dentin-containing tooth; positive regulation of protein kinase B signaling; positive regulation of protein localization to nucleus; positive regulation of Rho protein signal transduction; positive regulation of synaptic transmission, cholinergic; positive regulation of synaptic transmission, glutamatergic; presynaptic modulation of chemical synaptic transmission; regulation of gene expression; regulation of reactive oxygen species metabolic process; response to lipopolysaccharide; Rho protein signal transduction; signal transduction; skeletal muscle cell differentiation; skin development
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Reference #:
P07174
(UniProtKB)
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Alt. Names/Synonyms: Gp80-LNGFR; LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; Ngfr; p75; p75 ICD; p75NTR; RNNGFRR; Tnfrsf16; TNR16; Tumor necrosis factor receptor superfamily member 16
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Gene Symbols: Ngfr
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Molecular weight:
45,433 Da
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Basal Isoelectric point:
4.55
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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