TRPC3 iso3 Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily. Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 4q27
Cellular Component:  cation channel complex; plasma membrane
Molecular Function:  calcium channel activity; inositol 1,4,5 trisphosphate binding; metal ion binding; protein binding; store-operated calcium channel activity
Biological Process:  calcium ion transmembrane transport; calcium ion transport; manganese ion transport; phototransduction; positive regulation of calcium ion transport into cytosol; positive regulation of cardiac muscle hypertrophy in response to stress; regulation of cytosolic calcium ion concentration; response to ATP; response to calcium ion; single fertilization
Disease: Spinocerebellar Ataxia 41
Reference #:  Q13507-3 (UniProtKB)
Alt. Names/Synonyms: hTrp-3; hTrp3; SCA41; Short transient receptor potential channel 3; transient receptor potential cation channel subfamily C member 3; transient receptor potential cation channel subfamily C member 3 variant c; transient receptor potential cation channel, subfamily C, member 3; transient receptor potential channel 3; Transient receptor protein 3; TRP-3; TRP3; TRPC3; TRPC3 iso3
Gene Symbols: TRPC3
Molecular weight: 97,355 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TRPC3 iso3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein