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TRPC3 iso3
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily. Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 4q27 |
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Cellular Component:
cation channel complex; plasma membrane
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Molecular Function:
calcium activated cation channel activity; calcium channel activity; inositol 1,4,5 trisphosphate binding; metal ion binding; protein binding; store-operated calcium channel activity
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Biological Process:
calcium ion transmembrane transport; calcium ion transport; phototransduction; positive regulation of calcium ion transport into cytosol; positive regulation of cardiac muscle hypertrophy in response to stress; regulation of cytosolic calcium ion concentration; response to ATP; response to calcium ion; single fertilization
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Disease: Spinocerebellar Ataxia 41
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Reference #:
Q13507-3
(UniProtKB)
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Alt. Names/Synonyms: hTrp-3; hTrp3; SCA41; Short transient receptor potential channel 3; transient receptor potential cation channel subfamily C member 3; transient receptor potential cation channel subfamily C member 3 variant c; transient receptor potential cation channel, subfamily C, member 3; transient receptor potential channel 3; Transient receptor protein 3; TRP-3; TRP3; TRPC3; TRPC3 iso3
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Gene Symbols: TRPC3
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Molecular weight:
97,355 Da
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Basal Isoelectric point:
6.35
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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