BRF1 Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail. Binds to 3'-UTR ARE of numerous mRNAs. Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress. Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA. Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA. Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation. May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA. In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation. Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. Participates in the delivery of target ARE-mRNAs to processing bodies (PBs). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells. Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion. Plays a role in vasculogenesis and endocardial development. Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis. Plays a role in myoblast cell differentiation. Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009). Expressed in osteoblasts (PubMed:15465005). Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 12|12 C3
Cellular Component:  cytoplasm; cytosol; nucleus; P-body; ribonucleoprotein complex
Molecular Function:  14-3-3 protein binding; AU-rich element binding; DNA binding; metal ion binding; mRNA 3'-UTR AU-rich region binding; mRNA 3'-UTR binding; mRNA binding; protein binding; RNA binding
Biological Process:  3'-UTR-mediated mRNA destabilization; apoptotic process; cell proliferation; cellular response to cAMP; cellular response to epidermal growth factor stimulus; cellular response to fibroblast growth factor stimulus; cellular response to glucocorticoid stimulus; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to peptide hormone stimulus; cellular response to raffinose; cellular response to salt stress; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; chorio-allantoic fusion; embryonic organ development; ERK1 and ERK2 cascade; heart development; MAPK cascade; mesendoderm development; mRNA catabolic process; mRNA processing; mRNA transport; multicellular organism development; multicellular organism growth; negative regulation of erythrocyte differentiation; negative regulation of mitotic cell cycle phase transition; neural tube development; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay; p38MAPK cascade; phosphatidylinositol 3-kinase signaling; positive regulation of fat cell differentiation; positive regulation of intracellular mRNA localization; positive regulation of monocyte differentiation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; proepicardium development; protein kinase B signaling; regulation of B cell differentiation; regulation of gene expression; regulation of keratinocyte apoptotic process; regulation of keratinocyte differentiation; regulation of keratinocyte proliferation; regulation of mRNA 3'-end processing; regulation of mRNA stability; regulation of myoblast differentiation; regulation of stem cell proliferation; regulation of translation; response to wounding; spongiotrophoblast layer development; T cell differentiation in thymus; vasculogenesis
Reference #:  P23950 (UniProtKB)
Alt. Names/Synonyms: AW742437; AW743212; Berg36; Brf1; Butyrate response factor 1; cMG1; D530020L18Rik; ERF1; mRNA decay activator protein ZFP36L1; Protein TIS11B; Tis11b; TISB; Zfp36l1; zinc finger protein 36, C3H type-like 1
Gene Symbols: Zfp36l1
Molecular weight: 36,385 Da
Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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BRF1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein