XPB ATP-dependent 3'-5' DNA helicase, component of the core- TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage. One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with PUF60. Interacts with ATF7IP. Interacts with Epstein-Barr virus EBNA2. Belongs to the helicase family. RAD25/XPB subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC 3.6.4.12; Helicase; Transcription factor
Chromosomal Location of Human Ortholog: 18|18 B1
Cellular Component:  core TFIIH complex; holo TFIIH complex; nucleoplasm; nucleotide-excision repair factor 3 complex; nucleus; transcription factor TFIID complex
Molecular Function:  3'-5' DNA helicase activity; ATP binding; ATP-dependent DNA helicase activity; ATPase activity; DNA binding; DNA translocase activity; DNA-dependent ATPase activity; helicase activity; hydrolase activity; nucleotide binding; protein C-terminus binding; protein kinase activity; protein N-terminus binding; RNA polymerase II carboxy-terminal domain kinase activity; transcription factor binding
Biological Process:  apoptosis; cellular response to DNA damage stimulus; DNA repair; DNA topological change; embryonic organ development; hair cell differentiation; nucleotide-excision repair; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; positive regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter; protein localization; regulation of mitotic cell cycle phase transition; regulation of mitotic recombination; regulation of transcription, DNA-templated; regulation of transposition, RNA-mediated; response to oxidative stress; response to UV; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transcription-coupled nucleotide-excision repair; UV protection
Reference #:  P49135 (UniProtKB)
Alt. Names/Synonyms: Basic transcription factor 2 89 kDa subunit; BTF2 p89; BTF2-p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; Ercc-3; Ercc3; excision repair 3; excision repair cross-complementing rodent repair deficiency, complementation group 3; General transcription and DNA repair factor IIH helicase subunit XPB; OTTMUSP00000028389; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; Xeroderma pigmentosum group B-complementing protein; Xpb; Xpbc
Gene Symbols: Ercc3
Molecular weight: 89,126 Da
Basal Isoelectric point: 6.79  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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XPB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene