RASGRP3 Guanine nucleotide exchange factor (GEF) for Ras and Rap1. Belongs to the RASGRP family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras
Chromosomal Location of Human Ortholog: 2p22.3
Cellular Component:  guanyl-nucleotide exchange factor complex; integral component of plasma membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  calcium ion binding; diacylglycerol binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; kinase binding; protein binding; Ras guanyl-nucleotide exchange factor activity
Biological Process:  MAPK cascade; positive regulation of GTPase activity; Ras protein signal transduction; small GTPase mediated signal transduction
Reference #:  Q8IV61 (UniProtKB)
Alt. Names/Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor III; calcium- and diacylglycerol-regulated guanine nucleotide exchange factor III; CalDAG-GEFIII; GRP3; Guanine nucleotide exchange factor for Rap1; KIAA0846; RAS guanyl releasing protein 3; RAS guanyl releasing protein 3 (calcium and DAG-regulated); Ras guanyl-releasing protein 3; RASGRP3
Gene Symbols: RASGRP3
Molecular weight: 78,332 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RASGRP3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein