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RASGRP3
Guanine nucleotide exchange factor (GEF) for Ras and Rap1. Belongs to the RASGRP family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Ras |
| Chromosomal Location of human Ortholog: 2p22.3 |
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Cellular Component:
guanyl-nucleotide exchange factor complex; perinuclear region of cytoplasm; plasma membrane
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Molecular Function:
calcium ion binding; diacylglycerol binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; kinase binding; protein binding; small GTPase binding
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Biological Process:
MAPK cascade; positive regulation of GTPase activity; Ras protein signal transduction; small GTPase mediated signal transduction
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Reference #:
Q8IV61
(UniProtKB)
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Alt. Names/Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor III; calcium- and diacylglycerol-regulated guanine nucleotide exchange factor III; CalDAG-GEFIII; GRP3; Guanine nucleotide exchange factor for Rap1; KIAA0846; RAS guanyl releasing protein 3; RAS guanyl releasing protein 3 (calcium and DAG-regulated); Ras guanyl-releasing protein 3; RASGRP3
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Gene Symbols: RASGRP3
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Molecular weight:
78,332 Da
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Basal Isoelectric point:
6.33
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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GPCR Signaling to MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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