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DCC
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Belongs to the immunoglobulin superfamily. DCC family. Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. Note: This description may include information from UniProtKB.
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| Protein type: Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.; Tumor suppressor |
| Chromosomal Location of human Ortholog: 18q21.2 |
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Cellular Component:
axon; cytosol; integral component of postsynaptic density membrane; plasma membrane; Schaffer collateral - CA1 synapse
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Molecular Function:
netrin receptor activity; protein binding; transmembrane signaling receptor activity
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Biological Process:
anterior/posterior axon guidance; apoptotic process; axon guidance; axonogenesis; dorsal/ventral axon guidance; extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of collateral sprouting; negative regulation of dendrite development; negative regulation of netrin-activated signaling pathway; negative regulation of neuron projection development; netrin-activated signaling pathway; neuron migration; postsynaptic modulation of chemical synaptic transmission; regulation of neuron death; spinal cord ventral commissure morphogenesis
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Disease: Colorectal Cancer; Esophageal Cancer; Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2; Mirror Movements 1
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Reference #:
P43146
(UniProtKB)
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Alt. Names/Synonyms: Colorectal cancer suppressor; colorectal tumor suppressor; CRC18; CRCR1; DCC; DCC netrin 1 receptor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; HGPPS2; IGDCC1; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; MRMV1; Netrin receptor DCC; NTN1R1; putative colorectal tumor suppressor; Tumor suppressor protein DCC
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Gene Symbols: DCC
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Molecular weight:
158,457 Da
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Basal Isoelectric point:
6.32
Predict pI for various phosphorylation states
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