DCC Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Belongs to the immunoglobulin superfamily. DCC family. Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.; Tumor suppressor
Chromosomal Location of rat Ortholog: 18q12.1
Cellular Component:  axon; growth cone membrane; integral component of membrane; integral component of postsynaptic density membrane; membrane raft; plasma membrane; Schaffer collateral - CA1 synapse
Molecular Function:  identical protein binding; netrin receptor activity; protein binding; transcription coactivator activity
Biological Process:  anterior/posterior axon guidance; apoptotic process; axon guidance; dorsal/ventral axon guidance; netrin-activated signaling pathway; neuron migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; positive regulation of nucleic acid-templated transcription; postsynaptic modulation of chemical synaptic transmission; regulation of neuron death; response to amphetamine; spinal cord ventral commissure morphogenesis
Reference #:  Q63155 (UniProtKB)
Alt. Names/Synonyms: colorectal tumor suppressor; DCC; Deleted in Colorectal Cancer; deleted in colorectal carcinoma; Deleted in colorectal carcinoma, isoform CRA_a; Netrin receptor DCC
Gene Symbols: Dcc
Molecular weight: 157,941 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
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DCC

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene